The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as they display vast biological activities. Recent efforts concerning preparation oxindole using isatin-based multicomponent reactions (MCRs) constitute a advance generating druglike libraries fast and with wide scaffold diversity. In this review, we address those recent developments, exploring synthetic pathways activities described these compounds, namely antitumor, antibacterial, antifungal, antiparasitic, antiviral, antioxidant, anti-inflammatory central nervous system (CNS) pathologies. To add new depth to work, used well-established web-based free tool (SwissADME) evaluate most promising scaffolds what concerns properties, by evaluating compliance some valuable rules applied medicinal chemists both academia industrial settings (Lipinski, Ghose, Veber, Egan, Muegge). The aim review is endorse MCRs approach attain hit compounds bearing privileged structure, while critically scaffolds’ properties. • developments synthesized through reactions. Biological activity oxindoles derivatives. Evaluation properties SwissADME.